Instruction Category: Research

First night of sleep overconsolidation of trauma memory

Sleep disruption – measured with wearable / apps – during first week

FKBP5 (and multiple other genes) expression (Segman et al., 2005).

Hydrocortisone intervention (100-140 mg, intravenous, single bolus); it is much more effective if given at night (Zohar et al, 2011). (Weis et al, 2006, Delahanty et al, 2013).

High cognitive flexibility (Ben-Zion et al, 2018).

Prolonged exposure in aftermath: (Rothbaum 2012, 2014).

Skin Conductance – biomarker and vulnerability marker (Hinrichs 2017, 2019).

Propranolol (Pitman et al., 2006). In five studies the initial positive study was not supported, the meta-analysis does not support its use (Argolo et al, 2015).